総合生命科学部 バイオフォーラム2015 開催(2015.04.16)

 最先端の生命科学研究に触れてみませんか

日時 2015年4月16日(木) 15:00〜16:00(14:30開場)
場所 京都産業大学 15号館1階15102セミナー室
交通 ※キャンパス内に駐車場はありません。公共交通機関をご利用ください。
交通アクセス
備考 事前申込不要・入場無料・一般の方の参加歓迎
主催 京都産業大学 総合生命科学部

講師

Laurent Désaubry 博士(CNRS-Strasbourg University)

Development of novel anticancer agents that target prohibitins and the translation initiation factor eIF4a

 Flavaglines are a family of anticancer natural products that relieve the resistance to cancer chemotherapies and display a strong cytotoxicity that is specific to cancer cells in a low nanomolar range. Not only flavaglines are not toxic to non-cancer cells, but they protect normal cells from various stresses. Thus, we demonstrated for the first time that these compounds protect the heart and neurons from the adverse effects of cancer chemotherapies involving anthracyclines and cisplatin. We also identified the scaffold proteins prohibitins-1 and -2 (PHB1/2) as the molecular targets of flavaglines. We demonstrated that the binding of flavaglines to PHBs prevents interaction between PHBs and CRaf and, thereby, inhibits CRaf activation and subsequently CRaf-MEK-ERK signaling, which is critical to survival and proliferation of cancer cells. Flavaglines also directly inhibit another emerging target in oncology, the translation initiation factor eIF4a. In vivo data indicate that flavaglines could greatly improve the treatment of chemoresistant metastatic melanoma.

※本講演は英語講演となります。通訳はありませんので、ご注意ください。

 
PAGE TOP