総合生命科学部 バイオフォーラム2018開催(2019年2月21日)

2019.02.04

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イベント研究総合生命科学部

タンパク質動態研究所セミナー/第182回細胞生物学セミナー

Dr. Vivek Malhotra(CRG, Centre for Genomic Regulation / Barcelona, SPAIN)

「Building a machine for secretion of bulky collagens from endoplasmic reticulum」

How are collagen's bulky cargoes that are too big to fit into a conventional COPII vesicle exported from the ER? Our discovery of TANGO1 (Bard, Nature 2006; Saito, Cell 2009), a ubiquitously expressed, ER-exit-site-resident, transmembrane protein has made the pathway of collagen secretion amenable to molecular analysis. TANGO1 acts as a scaffold to connect collagens in the lumen to COPII coats on the cytoplasmic side of ER. However, the growth of the collagen containing mega transport carrier is not simply by accretion of a larger COPII coated patch of ER membrane, but instead by rapid addition of premade small vesicles. We have seen that TANGO1 rings the ER exit site and thus organizes a sub compartment within the ER. We have now mapped all the components that work in concert along with the cargo to assemble TANGO1 into a ring, suggesting that export of bulky collagens is by direct connection of ER exit site to the Golgi via transient tunnels created by the function of TANGO1.

日時 2019年2月21日(木) 16:00~17:30(15:45開場)
場所 京都産業大学 15号館1階15102セミナー室
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備考 事前申込不要・入場無料
本講演は英語講演となります。通訳はありませんので、ご注意ください。
主催 京都産業大学 総合生命科学部
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