総合生命科学部 バイオフォーラム2017開催(6月5日)

最先端の生命科学研究に触れてみませんか

第1部:京都産業大学タンパク質動態研究所セミナー/生物化学セミナー

Dr. Ramanujan S. Hegde(MRC Laboratory of Molecular Biology / UK)

「Mechanisms of protein quality control in the cytosol」

A large proportion of the cell's proteins must be segregated to membrane-bound organelles and multi-protein complexes. Failures in localization or assembly must be recognized by the cell and promptly degraded to avoid the accumulation of aberrant and potentially harmful proteins. Our group has taken a biochemical strategy to identify cytosolic factors that recognize mislocalized or unassembled proteins, and used reconstitution approaches to understand how they function. I will describe efforts over the past several years that have led to the discovery of new chaperone-like factors that prevent aggregation of mis-localized proteins and selectively target them for degradation. These factors are likely to play crucial roles in maintaining cytosolic protein homeostasis, and when mutated, may contribute to diseases of protein misfolding such as neurodegeneration.

第2部:京都産業大学タンパク質動態研究所セミナー/第177回細胞生物学セミナー

Dr. Peter Walter(University of California / USA、本学タンパク質動態研究所 招聘教授)

「From Protein Folding to Cognition : a Serendipitous Path of Discovery」

A screen for small molecule modulators of the unfolded protein response yielded ISRIB, a drug-like compound that with high efficacy renders cells insensitive to translational inhibition by phosphorylation of eIF2. ISRIB is an activator of eIF2B, eIF2's guanine nucleotide exchange factor, and a cognitive enhancer in rodents, significantly improving long-term memory of wild-type animals in behavioral assays.
日時 2017年6月5日(月) 開場 15:45/第1部 16:00~17:00/第2部 17:00~18:00
場所 京都産業大学 15号館1階15102セミナー室
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備考 事前申込不要・入場無料・一般の方の参加歓迎
本講演は英語講演となります。通訳はありませんので、ご注意ください。
主催 京都産業大学 総合生命科学部
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