Professor Hisato Kondoh

Area and Subject Taught Molecular Developmental Biology
Research Theme(s) Molecular developmental biology Research themes:
Intercellular signaling and transcriptional regulation in the developmental process
Academic Degrees PhD. Kyoto University
Keywords for Research Field Embryonic development, somatic cell differentiation, intercellular signaling, transcriptional regulation
Office Phone Number 075-705-1722
e-mail

Research Overview

All somatic cells of our body develop from epiblast, a cell population that develops in post-implantation embryos in the case of mammals. How a variety of somatic cell lineages develop from initially homogeneous epiblast is a fundamental problem of developmental biology, which we are investigating.
The approach we are taking is to investigate the regulation of cell lineage specification by SOX2 and other transcription factors, and the effects of intercellular signaling on the action of transcription factors. To this end, we analyze conditional knockout mouse embryos, where particular transcription factor genes are inactivated in developmental stage/cell lineage-specific manner. We also utilize epiblast stem cell lines and chicken embryos to manipulate epiblast cells with exogenous factors.
Among the somatic cell lineages, we are interested in those leading to neural, sensory, cardiac, somitic and digestive tract development.

Notable Publications and Works in the Last Three Years

  1. Sasado T, Kondoh H, Furutani-Seiki M, Naruse K. Mutation in cpsf6/CFIm68 (Cleavage and Polyadenylation Specificity Factor Subunit 6) causes short 3'UTRs and disturbs gene expression in developing embryos, as revealed by an analysis of primordial germ cell migration using the medaka mutant naruto. PLoS One. 12, e0172467 (2017).
  2. Iida H, Ishii Y, Kondoh H. Intrinsic lens potential of neural retina inhibited by Notch signaling as the cause of lens transdifferentiation. Dev Biol. 421, 118-125 (2017).
  3. Menuchin-Lasowski Y, Oren-Giladi P, Xie Q, Ezra-Elia R, Ofri R, Peled-Hajaj S, Farhy C, Higashi Y, Van de Putte T, Kondoh H, Huylebroeck D, Cvekl A, Ashery-Padan R. Sip1 regulates the generation of the inner nuclear layer retinal cell lineages in mammals. Development 143, 2829-2841 (2016).
  4. Kondoh H, Takada S, Takemoto T. Axial level-dependent molecular and cellular mechanisms underlying the genesis of the embryonic neural plate. Dev Growth Differ. 58, 427-436 (2016).
  5. Takemoto T, Abe T, Kiyonari H, Nakao K, Furuta Y, Suzuki H, Takada S, Fujimori T, Kondoh H. R26-WntVis reporter mice showing graded response to Wnt signal levels. Genes Cells. 21, 661-669 (2016).
  6. Yasumi T, Inoue M, Maruhashi M, Kamachi Y, Higashi Y, Kondoh H, Uchikawa M. Regulation of trunk neural crest delamination by δEF1 and Sip1 in the chicken embryo. Dev Growth Differ. 58, 205-214. (2016).
  7. Kondoh, H. & Lovell-Badge, R. (Eds). Sox2: Biology and Role in Development and Disease. To be published from Academic Press/Elsevier (2015)
  8. Porazinski, S., Wang, H., Yoichi Asaoka, Y., Behrndt, M., Miyamoto, T., Morita, H., Hata, S., Sasaki, T., Krens, SFG., Osada, Y., Asaka, S., Momoi, A., Linton, S., Miesfeld, JB., Link, BA., Takeshi Senga, Atahualpa Castillo-Morales, Araxi O. Urrutia, Nobuyoshi Shimizu, Nagase, H., Matsuura, S., Bagby, S., Hisato Kondoh, H., Nishina, H., Heisenberg, C-P & Furutani-Seiki, M. YAP is essential for tissue tension to ensure vertebrate 3D body shape. Nature 521, 217-221 (2015)
  9. Okamoto R, Uchikawa M & Kondoh H. Sixteen additional enhancers associated with the chicken Sox2 locus outside the central 50-kb region. Dev Growth Differ. 57, 24-39 (2015).
  10. Kondoh, H. & Kuroiwa, A. (Eds). New Principles in Developmental Processes (Springer, Tokyo, 2014).
  11. Matsuda K, & Kondoh H. Dkk1-dependent inhibition of Wnt signaling activates Hesx1 expression through its 5' enhancer and directs forebrain precursor development. Genes Cells. 19, 374-385 (2014).
  12. Yoshida M, Uchikawa M, Rizzoti K, Lovell-Badge R, Takemoto T & Kondoh H. Regulation of mesodermal precursor production by low-level expression of B1 Sox genes in the caudal lateral epiblast. Mech Dev. 132, 59-68 (2014).