Associate Professor Yasuyuki Tanahashi

Area and Subject Taught Veterinary Pharmacology
Research Theme(s) Regulation of smooth muscle contractility and associated functional disorders
Academic Degrees DVM (Gifu University), PhD (Veterinary Sciences, Gifu University)
Keywords for Research Field smooth muscle, receptors, ion channels, Ca2+, stress
Office Phone Number Not Public

Research Overview

Smooth muscle, which is located in the walls of the visceral organs, plays an important role in several processes in the body including modulating blood vessel tone, controlling gastrointestinal and genitourinary tract motility, and regulating airway resistance. Smooth muscle contractility is regulated by intracellular Ca2+, which is affected by various neurotransmitters and hormones that act on its receptors and ion channels. Structural and functional changes in the smooth muscle can lead to disorders such as hypertension, asthma, and irritable bowel syndrome. Our laboratory focuses on understanding 1) the mechanisms that regulate smooth muscle contractility, and 2) pathophysiology of diseases associated with smooth muscle abnormality.

Notable Publications and Works in the Last Three Years

  1. Picomolar, selective and subtype specific small-molecule inhibition of TRPC1/4/5 channels: Rubaiy HN, Ludlow MJ, Henrot M, Gaunt HJ, Miteva K, Cheung SY, Tanahashi Y, Hamzah N, Musialowski KE, Blythe NM, Appleby HL, Bailey MA, McKeown L, Taylor R, Foster R, Waldmann H, Nussbaumer P, Christmann M, Bon RS, Muraki K, Beech DJ. J. Biol. Chem., 292(20): 8158–8173, 2017
  2. Inhibitory effects of SKF96365 on the activities of K+ channels in mouse small intestinal smooth muscle cells: Y. Tanahashi, B. Wang, Y. Murakami, T. Unno, H. Matsuyama, H. Nagano and S. Komori, J. Vet. Med. Sci. 78(2): 203–211, 2016
  3. A study on Borna disease virus infection in domestic cats in Japan: A. Someya, R. Fukushima, M. Yoshida, Y. Tanahashi, T. Prapeuk, R. Iizuka, H. Hirami, A. Matsuda, S. Takahashi, G. Kurita, T. Kimura, M. Seo, M. Funaba, Y. Nishino, J. Vet. Med. Sci., 76(8): 1157-60, 2014