Professor Hiroki Takakuwa

Area and Subject Taught Infectious Disease
Research Theme(s) Study on ecology and pathogenicity of influenza viruses
Academic Degrees Ph.D.(Veterinary) Hokkaido University
Keywords for Research Field Avian influenza viruses, pathogenicity,host range
Office Phone Number 81-75-705-2977
e-mail

Research Overview

Currently, outbreaks of highly pathogenic avian influenza and other emerging and re-emerging diseases have caused serious economical and social disturbances worldwide. To control these infections is the most important. Our research is focused on: 1) The evolution and spread mechanism of pathogens such as avian influenza virus in nature. 2) Studies on the host range determinant in pathogens, mechanisms of pathogenesis and immune response of the hosts through in vivo and in vitro analyses of the host-parasite interactions. 3) Development of strategies for the prevention and control of the infections.

Notable Publications and Works in the Last Three Years

  1. Fujimoto, Y., Tomioka, Y., Ozaki, K., Takeda, K., Suyama, H., Yamamoto, S., Takakuwa, H., Morimatsu, M., Uede, T., Ono, E. Comparison of the antiviral potential among soluble forms of herpes simplex virus type-2 glycoprotein D receptors, herpes virus entry mediator a, nectin-1 and nectin-2, in transgenic mice. Journal of General Virology, 98 (7), 1815-1822. 2017.
  2. Okamatsu, M., Ozawa, M., Soda, K., Takakuwa, H., Haga, A., Hiono, T., Matsuu, A., Uchida, Y., Iwata, R., Matsuno, K., Kuwahara, M., Yabuta, T., Usui, T., Ito, H., Onuma, M., Sakoda, Y., Saito, T., Otsuki, K., Ito, T., Kida, H. Characterization of highly pathogenic avian influenza virus A(H5N6), Japan, November 2016. Emerging Infectious Diseases, 23, 691-695. 2017.
  3. Usui, T., Soda, K., Tomioka, Y., Ito, H., Yabuta, T., Takakuwa, H., Otsuki, K., Ito, T., Yamaguchi, T. Characterization of clade 2.3.4.4 H5N8 highly pathogenic avian influenza viruses from wild birds possessing atypical hemagglutinin polybasic cleavage sites. Virus Genes, 53, 44-51. 2017.
  4. Fujimoto, Y., Tomioka, Y., Takakuwa, H., Uechi, G.-I., Yabuta, T., Ozaki, K., Suyama, H., Yamamoto, S., Morimatsu, M., Mai, L.Q., Yamashiro, T., Ito, T., Otsuki, K., Ono, E. Cross-protective potential of anti-nucleoprotein human monoclonal antibodies against lethal influenza A virus infection. Journal of General Virology, 97, 2104-2116. 2016.
  5. Fujimoto, Y., Ozaki, K., Iwamori, N., Takakuwa, H., Ono, E. Accumulation of a soluble form of human nectin-2 is required for exerting the resistance against herpes simplex virus type 2 infection in transfected cells . Acta Virologica, 60, 41-48. 2016.
  6. Varga, D., Herédi, J., Kánvási, Z., Ruszka, M., Kis, Z., Ono, E., Iwamori, N., Iwamori, T., Takakuwa, H., Vécsei, L., Toldi, J., Gellért, L. Systemic L-Kynurenine sulfate administration disrupts object recognition memory, alters open field behavior and decreases c-Fos immunopositivity in C57Bl/6 mice. Frontiers in Behavioral Neuroscience, 9, A157, 2015.