Professor Hidetaka Shiratori

Area and Subject Taught Mechanism of organogenesis
Research Theme(s) Molecular mechanism of morphological changes in organogenesis
Academic Degrees DVM, Ph.D.
Keywords for Research Field Organogenesis, Morphological change, Axis formation
Office Phone Number Not Public

Research Overview

Several visceral organs are left-right (L-R) asymmetrically located in vertebrates. In embryonic development, the visceral organs are L-R symmetrically initiated, and then their shape is asymmetrically changed. We want to know the mechanism for the generation of L-R asymmetry.
①How is the asymmetric expression of the genes regulated?
②How is the shape of the visceral organs changed?
We analyze the role and transcriptional mechanism of the genes that are asymmetrically expressed focusing on the differences between left and right in cell migration, cell proliferation, cell shape and cell death, using several mutant and transgenic mice.

Notable Publications and Works in the Last Three Years

  • A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking.
    Minegishi K, Hashimoto M, Ajima R, Takaoka K, Shinohara K, Ikawa Y, Nishimura H, McMahon AP, Willert K, Okada Y, Sasaki H, Shi D, Fujimori T, Ohtsuka T, Igarashi Y, Yamaguchi TP, Shimono A, Shiratori H, Hamada H.
    Dev Cell. 2017 Mar 13;40(5):439-452.
  • TTC25 Deficiency Results in Defects of the Outer Dynein Arm Docking Machinery and Primary Ciliary Dyskinesia with Left-Right Body Asymmetry Randomization.
    Wallmeier J, Shiratori H, Dougherty GW, Edelbusch C, Hjeij R, Loges NT, Menchen T, Olbrich H, Pennekamp P, Raidt J, Werner C, Minegishi K, Shinohara K, Asai Y, Takaoka K, Lee C, Griese M, Memari Y, Durbin R, Kolb-Kokocinski A, Sauer S, Wallingford JB, Hamada H, Omran H.
    Am J Hum Genet. 2016 Aug 4;99(2):460-9.
  • Single-Cell Expression Profiling Reveals a Dynamic State of Cardiac Precursor Cells in the Early Mouse Embryo.
    Kokkinopoulos I, Ishida H, Saba R, Ruchaya P, Cabrera C, Struebig M, Barnes M, Terry A, Kaneko M, Shintani Y, Coppen S, Shiratori H, Ameen T, Mein C, Hamada H, Suzuki K, Yashiro K.
    PLoS One. 2015 Oct 15;10(10):e0140831.
  • Self-regulated left-right asymmetric expression of Pitx2c in the developing mouse limb.
    Shiratori H, Yashiro K, Iwai N, Oki S, Minegishi K, Ikawa Y, Kanata K, Hamada H.
    Dev Biol. 2014 Nov 15;395(2):331-41.
  • TGFβ signaling in establishing left-right asymmetry.
    Shiratori H, Hamada H.
    Semin Cell Dev Biol. 2014 Aug;32:80-4.