Professor Toshiyuki Saito

Area and Subject Taught Neurobiology
Research Theme(s) Stress Disorders and Regeneration of Neurons in the Brain
Academic Degrees DVM (Hokkaido University), PhD (Hokkaido University)
Keywords for Research Field Stress, Neurodegeneration, Stem Cell
Office Phone Number 81-75-705-3073

Research Overview

The physiological reaction to stressors involves activation of the hypothalamic pituitary adrenal (HPA) axis and the sympathetic nervous system. During acute stress, activation of the HPA axis and the sympathetic nervous system lasts only for a short time. But, chronic activation of both systems may increase a risk for anxiety and other stress disorders. Dysregulation of functional coupling in the brain is considered to underlie anxiety and stress disorders. However, it remains unclear how chronic stress disrupts regulatory systems in the brain, which generates anxiety and stress disorders with degeneration of neurons. In our laboratory, the neural signaling and regulation which are sensitive to stressors have been surveyed in the central nervous system, and how damaged neurons by stress can be regenerated and repaired using experimental animals.

Notable Publications and Works in the Last Three Years

  1. Saito T, Watanabe E, Sasaki S. Brain atlas of the miniature pig to establish new animal model for image-assisted stereotaxic surgery. Database of Grants-in-Aids for Scientific Research, Japan (, 2016.
  2. Nishino Y, Saito T. Influence of virus infection in stress-induced neuronal dysfunction in the mouse brain. The Bulletin of the Research Institute of Advanced Technology, Kyoto Sangyo University 13: 69-80, 2014.
  3. Uga M, Saito T, Sano T, Yokota H, Oguro K, Rizki EE, Mizutani T, Katura T, Dan I, Watanabe E. Direct cortical hemodynamics mapping of somatotopy of pig nostril sensation by functional Near-infrared Cortical Imaging (fNCI). Neuroimage 91: 138-145, 2014.