Professor Toshiya Endo
|Area and Subject Taught||Structural Biology, Molecular Cell Biology|
|Research Theme(s)||How to make mitochondria from proteins and lipids|
|Academic Degrees||Ph.D (D. Sci)|
|Keywords for Research Field||mitochondria, protein transport, lipid transport|
|Office Phone Number||Not Public|
Mitochondria, essential organelles in eukaryotic cells, play central roles in energy production, metabolic processes, cellular signaling, and many processes related to health, disease, and aging. Since mitochondria are only generated by growth and division of preexisting mitochondria or require them as templates, mitochondrial growth relies on precise import and synthesis of their resident proteins and lipids. The cell thus has a sophisticated system to achieve efficient protein and lipid transport into mitochondria, quality control and coordination of mitochondrial functions with other organelles. We are studying the mechanisms of how the cell makes mitochondria and how the it maintains mitochondrial structures and functions by taking divergent approaches covering molecular genetics, biochemistry, cell biology, and structural biology.
Notable Publications and Works in the Last Three Years
- Y. Kakimoto, S. Tashiro, R. Kojima, Y. Morozumi, T. Endo, and Y. Tamura Visualizing multiple inter-organelle contact sites using the organelle-targeted split-GFP system Sci. Rep. 8, 6175 (2018)
- A. Matsumura, J. Higuchi, Y. Watanabe, K. Aoki, S. Akabane, T. Endo, and T. Oka Inactivation of cardiolipin synthase triggers changes in mitochondrial morphology FEBS Lett. 592, 209-218 (2018)
- S. Kawano, Y. Tamura, R. Kojima, S. Bala, E. Asai, A. H. Michel., B. Kornmann, I. Riezman, H. Riezman, Y. Sakae, Y. Okamoto., and T. Endo Structure-function insights into direct lipid transfer between membranes by Mmm1-Mdm12 of ERMES.
J. Cell Biol. 217, 959-974 (2018)
- S. Arakawa, K. Yunoki, T. Izawa, Y. Tamura, S. Nishikawa, and T. Endo
Quality control of nonstop membrane proteins at the ER membrane and in the cytosol.
Sci. Rep. 6, Article number: 30795 (2016)
- N. Miyata, Y. Watanabe, Y. Tamura, T. Endo, and O. Kuge
Phosphatidylserine transport by Ups2–Mdm35 in respiration-active mitochondria
J. Cell Biol. 214, 77-88 (2016)
- Y. Tamura, Y. Harada, S. Nishikawa, K. Yamano, M. Kamiya, T. Shiota, T. Kuroda, O. Kuge, H. Sesaki, K. Imai, K. Tomii, and T. Endo
Tam41 is a CDP-diacylglycerol synthase required for cardiolipin biosynthesis in mitochondria
Cell Metab. 17, 709-718 (2013)
- T. Shiota, K. Imai, J. Qiu, V. L. Hewitt, K. Tan, H. Shen, N. Sakiyama, Y. Fukasawa, S. Hayat, M. Kamiya, A. Elofsson, K. Tomii, P. Horton, N. Wiedemann, N. Pfanner, T Lithgow, T. Endo
Science 349, 1544-1548 (2015)
- Y. Watanabe, Y. Tamura, S. Kawano, and T. Endo
Structural and mechanistic insights into phospholipid transfer by Ups1–Mdm35 in mitochondria Nature Commun. 6, Article number: 7922 (2015)
- Takano, T. Kajita, and M. Mochizuki, T. Endo, and T. Yoshihisa
Cytosolic Hsp70 and co-chaperones constitute a novel system for tRNA import into the nucleus.
eLife 4, e04659 (2015)