Professor Toshiya Endo
|Area and Subject Taught||Structural Biology, Molecular Cell Biology|
|Research Theme(s)||How to make mitochondria from proteins and lipids|
|Academic Degrees||Ph.D (D. Sci)|
|Keywords for Research Field||mitochondria, protein transport, lipid transport|
|Office Phone Number||Not Public|
Mitochondria, essential organelles in eukaryotic cells, play central roles in energy production, metabolic processes, cellular signaling, and many processes related to health, disease, and aging. Since mitochondria are only generated by growth and division of preexisting mitochondria or require them as templates, mitochondrial growth relies on precise import and synthesis of their resident proteins and lipids. The cell thus has a sophisticated system to achieve efficient protein and lipid transport into mitochondria, quality control and coordination of mitochondrial functions with other organelles. We are studying the mechanisms of how the cell makes mitochondria and how the it maintains mitochondrial structures and functions by taking divergent approaches covering molecular genetics, biochemistry, cell biology, and structural biology.
Notable Publications and Works in the Last Three Years
- S. Arakawa, K. Yunoki, T. Izawa, Y. Tamura, S. Nishikawa, and T. Endo
Quality control of nonstop membrane proteins at the ER membrane and in the cytosol.
Sci. Rep. 6, Article number: 30795 (2016)
- N. Miyata, Y. Watanabe, Y. Tamura, T. Endo, and O. Kuge
Phosphatidylserine transport by Ups2–Mdm35 in respiration-active mitochondria
J. Cell Biol. 214, 77-88 (2016)
- Y. Tamura, Y. Harada, S. Nishikawa, K. Yamano, M. Kamiya, T. Shiota, T. Kuroda, O. Kuge, H. Sesaki, K. Imai, K. Tomii, and T. Endo
Tam41 is a CDP-diacylglycerol synthase required for cardiolipin biosynthesis in mitochondria
Cell Metab. 17, 709-718 (2013)
- T. Shiota, K. Imai, J. Qiu, V. L. Hewitt, K. Tan, H. Shen, N. Sakiyama, Y. Fukasawa, S. Hayat, M. Kamiya, A. Elofsson, K. Tomii, P. Horton, N. Wiedemann, N. Pfanner, T Lithgow, T. Endo
Science 349, 1544-1548 (2015)
- Y. Watanabe, Y. Tamura, S. Kawano, and T. Endo
Structural and mechanistic insights into phospholipid transfer by Ups1–Mdm35 in mitochondria Nature Commun. 6, Article number: 7922 (2015)
- Takano, T. Kajita, and M. Mochizuki, T. Endo, and T. Yoshihisa
Cytosolic Hsp70 and co-chaperones constitute a novel system for tRNA import into the nucleus.
eLife 4, e04659 (2015)
- Y. Tamura, H. Sesaki and T. Endo
Phospholipid transport via mitochondria.
Traffic 15, 933-945 (2014)
- F. Koyano, K. Okatsu, H. Kosako, Y. Tamura, E. Go, M. Kimura, Y. Kimura, H. Tsuchiya, H. Yoshihara, T. Hirokawa, T. Endo, E. A. Fon, J. F. Trempe, Y. Saeki, K. Tanaka, and N. Matsuda
Ubiquitin is phosphorylated by PINK1 to activate parkin.
Nature 510, 162-166 (2014)
- Jiyao Song, Yasushi Tamura, Tohru Yoshihisa, and Toshiya Endo
A novel import route for an N-anchor mitochondrial outer membrane protein aided by the TIM23 complex
EMBO Rep. 15, 670-677 (2014)