Professor Hiroki Takakuwa

Area and Subject Taught Infectious Disease
Research Theme(s) Study on ecology and pathogenicity of avian influenza viruses
Academic Degrees Ph.D.(Veterinary) Hokkaido University
Keywords for Research Field Avian influenza viruses, pathogenicity,host range
Office Phone Number 81-75-705-2977
e-mail

Research Overview

Currently, outbreaks of highly pathogenic avian influenza and other emerging and re-emerging diseases have caused serious economical and social disturbances worldwide. To control these infections is the most important. Our research is focused on: 1) The evolution and spread mechanism of pathogens such as avian influenza virus in nature. 2) Studies on the host range determinant in pathogens, mechanisms of pathogenesis and immune response of the hosts through in vivo and in vitro analyses of the host-parasite interactions. 3) Development of strategies for the prevention and control of the infections.

Notable Publications and Works in the Last Three Years

  1. Fujimoto, Y., Ozaki, K., Maeda, M., Nishijima, K.-I., Takakuwa, H., Otsuki, K., Kida, H., Ono, E., Resistance to influenza A virus infection in transformed cell lines expressing an anti-PB2 monoclonal antibody. Veterinary Journal, 198 (2), pp. 487-493, 2013
  2. Takakuwa, H., Yamashiro, T., Le, M.Q., Phuong, L.S., Ozaki, H., Tsunekuni, R., Usui, T., Ito, H., Yamaguchi, T., Ito, T., Murase, T., Ono, E., Otsuki, K., The characterization of low pathogenic avian influenza viruses isolated from wild birds in northern Vietnam from 2006 to 2009. Comparative Immunology, Microbiology and Infectious Diseases, 36 (6), pp. 581-590, 2013
  3. Hotta, K., Takakuwa, H., Yabuta, T., Ung, T.T.H., Usui, T., Nguyen, H.L.K., Le, T.T., Le, M.Q., Yamaguchi, T., Otsuki, K., Ito, T., Murase, T., Yamashiro, T., Antibody survey on avian influenza viruses using egg yolks of ducks in Hanoi between 2010 and 2012. Veterinary Microbiology, 166 (1-2), pp. 179-183, 2013
  4. Hotta, K., Takakuwa, H., Le, Q.M.T., Phuong, S.L., Murase, T., Ono, E., Ito, T., Otsuki, K., Yamashiro, T., Isolation and characterization of H6N1 and H9N2 avian influenza viruses from Ducks in Hanoi, Vietnam. Virus Research, 163 (2), pp. 448-453, 2012
  5. Takakuwa, H., Yamashiro, T., Le, M.Q., Phuong, L.S., Ozaki, H., Tsunekuni, R., Usui, T., Ito, H., Morimatsu, M., Tomioka, Y., Yamaguchi, T., Ito, T., Murase, T., Ono, E., Otsuki, K., Molecular epidemiology of avian influenza viruses circulating among healthy poultry flocks in farms in northern Vietnam. Preventive Veterinary Medicine, 103 (2-3), pp. 192-200, 2012