Professor Toshiyuki Saito

Area and Subject Taught Neurobiology
Research Theme(s) Stress Disorders and Regeneration of Neurons in the Brain
Academic Degrees DVM (Hokkaido University), PhD (Hokkaido University)
Keywords for Research Field Stress, Neurodegeneration, Stem Cell
Office Phone Number 81-75-705-3073

Research Overview

The physiological reaction to stressors involves activation of the hypothalamic pituitary adrenal (HPA) axis and the sympathetic nervous system. During acute stress, activation of the HPA axis and the sympathetic nervous system lasts only for a short time. But, chronic activation of both systems may increase a risk for anxiety and other stress disorders. Dysregulation of functional coupling in the brain is considered to underlie anxiety and stress disorders. However, it remains unclear how chronic stress disrupts regulatory systems in the brain, which generates anxiety and stress disorders with degeneration of neurons. In our laboratory, the neural signaling and regulation which are sensitive to stressors have been surveyed in the central nervous system, and how damaged neurons by stress can be regenerated and repaired using experimental animals.

Notable Publications and Works in the Last Three Years

  1. Uga M, Saito T, Sano T, Yokota H, Oguro K, Rizki EE, Mizutani T, Katura T, Dan I, Watanabe E. Direct cortical hemodynamics mapping of somatotopy of pig nostril sensation by functional Near-infrared Cortical Imaging (fNCI). Neuroimage (in press)
  2. Ponmanickam P, Archunan G, Achiraman S, Sankar R, Saito T, Habara Y. Preputial gland activates olfactory receptor neurons in rat: Calcium imaging study using laser scanning confocal microscopy. Indian Journal of Biochemistry and Biophysics 50:242-246, 2013.
  3. Saito T, Uga M, Tsuzuki D, Yokota H, Oguro K, Yamamoto T, Dan I, Watanabe E. Evoked potential mapping of the rostral region by frameless navigation system in Mexican hairless pig. Journal of Neuroscience Methods 212:100-105, 2013.
  4. Saito T, Fujiwara S-E, Hisakura K, Ohkohchi N, Akema T, Sasamori S, Konno K,Kobayashi E and Yamaguchi T. Telemetry system for recording neural activities in pigs ‒ comparison with cable system. Brain Research Bulletin 84: 103-109, 2011.