Triage in the ER : Managing protein quality control decisions in the early secretory pathway

講師

Dr. Ron Kopito
(Stanford University, USA)

　The ERAD system recognizes and destroys a highly diverse array of proteins including folding-defective mutants, unassembled subunits of oligomeric complexes and even correctly folded ER resident proteins in response to metabolic signals. In this lecture I will present recent work focused on producing a fine-grained map of the Hrd1 ubiquitin ligase complex and its interaction with the glycan recognition machinery that underlies the “molecular triage” process by which ERAD substrates are identified.

※本講演は英語講演となります。通訳はありませんので、ご注意ください。