Protein folding homeostasis in the Endoplasmic Reticulum

講師

Dr. David Ron
University of Cambridge (UK)

　The endoplasmic reticulum is distinct from other protein folding compartments not only by certai biochemical peculiarities (N-linked glycosylation, disulfide bond formation, proline hydroxylation, etc.) but also by the unusual high turnover of it clients and by their fluctuating load. These features, prominent in professional secretory cells, have favoured the evolution of cellular adaptations that match the organelle’s capacity to process client proteins with the demands placed on it. Some details of these adaptations will be presented and discussed.